The 2017 International Conference on High Performance Computing & Simulation (HPCS 2017) will be held on July 17 – 21, 2017 in Genoa, Italy (Tentative). Under the theme of “HPC and Modeling & Simulation for the 21st Century,” HPCS 2017 will focus on a wide range of the state-of-the-art as well as emerging topics pertaining to high performance and large scale computing systems at both the client and backend levels. Continuing the great success of previous HPCS events, HPCS 2017 is anticipated to attract a large number of high-quality submissions and stimulate cutting-edge research discussions among many pioneering researchers and scientists as well as industry engineers and leaders from all around the world.