IISWC is the premier international conference dedicated to the understanding and characterization of workloads that run on all types of computing systems. Whether they are PDAs/smartphones at the low end or supercomputers at the high end, the design of future computing machines can be significantly improved if we understand the characteristics of the workloads that are expected to run on them. IISWC 2012 will focus on characterizing and understanding these modern computer applications.