We introduce the Intel® Simulation and Analysis Engine (Intel® SAE) — a framework for full-system instruction-level instrumentation of “ring 0” (privileged) and “ring 3” (user-level) code behavior. When plugged-in to a Wind River® Simics Virtual Platform, Intel® SAE boots native operating systems (e.g. Linux and Windows, as well as Android), and runs unmodified binaries while facilitating flexible and customizable instruction-level instrumentation of everything executing on the CPU, i.e. BIOS, kernel, drivers and kernel and user-space processes.